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 Table of Contents  
ORIGINAL ARTICLE
Year : 2020  |  Volume : 14  |  Issue : 2  |  Page : 70-73

A study on the effect of manual hyperinflation on oxygenation and hemodynamic parameters in mechanically ventilated patients after valve replacement surgery


1 Department of Physiotherapy, The Neotia University, Sarisa, West Bengal, India
2 Department of Physiotherapy, School of Health Sciences, Garden City University, Bengaluru, Karnataka, India

Date of Submission22-May-2020
Date of Decision19-Aug-2020
Date of Acceptance11-Oct-2020
Date of Web Publication31-Dec-2020

Correspondence Address:
Dr. Srijani Banerjee
43, Shibtala Street, Uttarpara - 712 258, West Bengal
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/PJIAP.PJIAP_29_20

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  Abstract 


BACKGROUND: Valve replacement surgeries being a major surgery require general anesthesia. Patients are kept on mechanical ventilation postoperatively which can cause some major dysfunctions of the respiratory and circulatory systems of the human body. Manual hyperinflation (MHI) is a technique that provides a tidal volume greater than the baseline volume and produces a turbulent flow that brings benefits such as improvement of static compliance of the respiratory system, increased oxygenation, mobilization of secretions, and recruitment of collapsed areas of the lung.
OBJECTIVES: The aim of this study was to compare the effectiveness of MHI in valve replacement patients on mechanical ventilation in terms of SpO2, heart rate (HR), respiratory rate (RR), blood pressure (BP), mean arterial pressure (MAP), and rate pressure product (RPP).
MATERIALS AND METHODS: Thirty cardiothoracic intensive care unit patients who were intubated and mechanically ventilated after valve replacement surgery were given 3–4 MHI breaths with an O2 flow rate of 15 L/min for 6–8 sets or till secretions were heard. Means of the pretreatment and posttreatment values were calculated and compared by the paired t-test.
Results: The results from the statistical analysis show that SpO2 remained almost same (P = 0.499). However, heart rate increased significantly (P = 0.048) after MHI. There was no adverse change in RPP (P = 0.409), but BP (P = 0.00 and 0.006), RR (P = 0.000), and MAP decreased significantly (P = 0.0005).
CONCLUSION: The MHI technique seems to promote more improvement in hemodynamic parameters than in oxygenation.

Keywords: Blood pressure, cardiac valve replacement, hyperinflation, mechanical ventilation, rate pressure product


How to cite this article:
Banerjee S, Suresh A. A study on the effect of manual hyperinflation on oxygenation and hemodynamic parameters in mechanically ventilated patients after valve replacement surgery. Physiother - J Indian Assoc Physiother 2020;14:70-3

How to cite this URL:
Banerjee S, Suresh A. A study on the effect of manual hyperinflation on oxygenation and hemodynamic parameters in mechanically ventilated patients after valve replacement surgery. Physiother - J Indian Assoc Physiother [serial online] 2020 [cited 2021 Jan 19];14:70-3. Available from: https://www.pjiap.org/text.asp?2020/14/2/70/305839




  Introduction Top


Cardiac surgical procedures are associated with a high incidence (17%–88%) of postoperative complications.[1] Postoperative pulmonary complications among patients undergoing cardiac surgery contribute to longer stay in intensive care and increase mortality in hospital.[2],[3]

Surgery for valvular heart disease has undergone important refinements during the past several years. At the same time, it has also paved way for some other major dysfunctions of the respiratory and circulatory systems of the human body. All patients of valve replacement surgery require mechanical ventilation. However, patients receiving mechanical ventilation may have an increased risk of sputum retention, atelectasis, and pneumonia, making ventilation weaning more difficult and resulting in excess morbidity and mortality.[4],[5]

Patients with valvular diseases also present with respiratory symptoms hence making them more prone for post-surgical complications. These complications can be avoided and prevented with early and proper chest physiotherapy intervention.

Several chest physiotherapy techniques have been used with mechanically-ventilated patients. However, patients who undergo thoracic or cardiac surgery have anterior or lateral incisions, as well as bone fractures and instability of the sternum and ribs, which limit the application of some manual techniques.[4]

Manual hyperinflation (MHI) is a technique that provides a tidal volume greater than the baseline volume and produces a turbulent flow that brings benefits such as improvement of static compliance of the respiratory system, increased oxygenation, mobilization of secretions, and recruitment of collapsed areas of the lung.[6] It is usually used as amelioration to other physiotherapy techniques or only when other techniques of secretion clearance such as postural drainage, percussion, and vibration are not sufficient or effective. However, the efficacy of MHI when given in isolation is not clearly established. The effect of MHI with respect to the clearance of excess and thick secretion and lung compliance has been well established,[7] but there is limited evidence of the effect of MHI on oxygen saturation and hemodynamics in post-valve replacement surgery patients who are on mechanical ventilation. Despite massive research MHI still remains a very controversial and oft a misjudged technique owing to the complications that might arise when not given with care. The effect of MHI on the postsurgical ventilated patients gets overshadowed when given alongside other chest physiotherapy techniques.

This study attempts to define the efficacy of MHI as an isolated physiotherapy maneuver and its effect on the oxygen saturation and hemodynamics of valve replacement surgery patients on mechanical ventilator support. The outcome of this study could yield greater understanding in the relevant importance of MHI in intensive care units (ICUs) and may prove to be useful in treating patients which might improve the gaseous exchange and reduce the ill-effects of mechanical ventilators.


  Materials and Methods Top


Methods

After getting the formal consent from the ethical committee of the concerned institutions, 30 mechanically ventilated postsurgical valve replacement surgery patients who fulfilled the inclusion criteria and had given informed consent were selected into one single group. All the participants had been informed about the study preoperatively, and a prior consent was obtained from them before the surgery and before commencing the study.

Those who were excluded were as follows: (1) patients with unstable BP, (2) patients with arrhythmias, (3) hemoptysis, (4) high risk/critically ill patients, (5) undrained pneumothorax, (6) patients with neurological disorders, (7) patients with traumatic injuries, and (8) patients with chest deformity.[8]

The MHI was given using the Laerdal circuit[9] in the following manner – the patient was positioned to supine lying. The vital signs of the patients were checked first. The necessary data (positive end-expiratory pressure [PEEP], tidal volume, and peak airway pressure) were noted from the ventilator. The bagging circuit was then connected to the oxygen supply and the flow rate was set at 15 L/min. The patient was removed from the ventilator circuit and connected to the bagging circuit. Few normal tidal breaths were given to the patient to understand the compliance of the patient's lungs. Then the subjects were given 3–4 hyperinflation followed by tidal volume breaths. The MHI technique was given in three phases. A slow inspiration was given followed by inspiratory hold phase of 2–3 s. The bag was then rapidly released for forceful expiration. This was continued till secretions were heard or for 6–8 sets and after that suctioning was done. Apart from the above-mentioned procedure, no other physiotherapy technique was added. This was done to understand the effect of MHI in isolation.

The heart rate (HR), blood pressure (BP), respiratory rate (RR) and the SpO2 were recorded from the MEC – 2000 Mindray ICU Monitor. The mean arterial pressure (MAP) and rate pressure product (RPP) were calculated manually. The first set of readings of the above parameters for the selected participants was recorded from the monitor before giving any physiotherapy. The second set of readings was taken after the MHI was done.

Statistical analysis

The two sets of data were compared. They were analyzed using the standard method in Microsoft Excel. The data were expressed in terms of mean and standard deviation which was calculated and compared by the paired t-test.


  Results Top


Thirty patients, which included 24 female (80%) and 6 male patients (20%) who met the inclusion criteria were included in the study. Demographic data for the patients and data from the ventilator are shown in [Table 1].
Table 1: Demographic data and ventilator data of patients

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Out of 30 patients, 16 underwent mitral valve replacement, 6 had aortic valve replacement, 6 had double valve replacement, and 4 patients underwent pulmonary valve replacement.

The results as seen in [Table 2], can be summarized as follows: On comparing the recorded values, it was found most of the parameters underwent significant change after MHI. There was a significant increase in the HR (P = 0.048) after MHI. The mean HR increased from 108.73 ± 18.55 to 120.23 ± 18.93. The change in BP was also found to be significant for both systolic and diastolic BP (P = 0.00 and 0.006, respectively). As opposed to the HR, the systolic BP decreased to 110.26 ± 13.33 from a preintervention mean of 124.66 ± 16.66 and the diastolic BP decreased from 69.56 ± 10.54 to 61.7 ± 9.12.
Table 2: Comparative data for the dependent variables for the patients (mean±standard deviation)

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In case of RR, the postintervention values were lower than the preintervention values, the mean values being 21.6 ± 6.85 and 18.3 ± 7.39, respectively. The decrease in RR was found to be statistically significant (P = 0.000). Contrary to this, no significant difference was found in SpO2 (P = 0.499). The mean values before and after MHI are 97.53 ± 3.45 and 98.83 ± 2.50, respectively. Even though there was increase in SpO2 after MHI, it was not statistically significant.

There was a significant difference between the preintervention and postintervention values of MAP (P = 0.0005). The mean value before MHI is 87.86 ± 11.32 and after MHI, the mean value is 77.81 ± 9.19. The RPP did not change significantly (P = 0.409). The preintervention and postintervention mean for RPP was 13.40 ± 2.12 and 13.22 ± 2.49, respectively.

The mean and standard deviation is presented in the tables and figures. Comparison of the preintervention and postintervention values of each outcome measure is done using the paired t-test and the P value inference is done.


  Discussion Top


This retrospective study deals with patients in the acute phase of their surgery, i.e., postoperative day “1;” therefore, there was a major contribution of anesthesia to abnormalities of gaseous exchange. The patients studied were representatives of a cardiothoracic ICU (CTICU) population who were on synchronized intermittent mechanical ventilation mode of ventilation to assist with their extubation. The parameters of the ventilator were based on the protective ventilator settings consisting of tidal volume of approximately 6 ml/kg, PEEP of 6–12 cm H2O, and recruitment maneuvers that decrease the development of acute respiratory distress syndrome, pulmonary infection, and atelectasis.[10]

The samples were selected according to the convenient sampling. All patients were selected preoperatively and then assessed postoperatively. Out of the selected patients, three patients could not be included in the study due to various factors such as arrhythmia and unstable BP in two patients and self-extubation in one case. Three other patients who fulfilled the inclusion criteria and were willing to participate were included.

The MHI was administered using the Laerdal circuit,[9] and the protocol in this study was based on the works of L. Denehy, S. Berney, and J. A. Pryor. The technique was in three phases – slow inspiration, 2–3 s inspiratory hold, and forceful expiration. O2 was kept at 15 L/min. 3–4 hyperinflations were given for a set of 6–8 times or till secretions were heard.[7]

The tidal volume applied in MHI is aimed to be a volume which is approximately 150–200 percent greater than the tidal volume delivered by a mechanical ventilator and two to three times the resting tidal volume of a normal subject. The peak airway pressures reach approximately 40 cm H2O. The two-handed technique using the Laerdal circuit is known to give the aimed tidal volume and “slow” inflation flow rates.[11],[12],[13]

Consistent with the previous studies, the results of this study showed that even though there was an increase in SpO2 after MHI, the increase was not statistically significant with the P value at 0.499. Blattner et al. reported that patients on mechanical ventilation after myocardial re-vascularization had better oxygenation and static lung compliance after manual lung hyperinflation. A significant difference was seen in the systolic BP with P value of 0.000 and for diastolic BP the P value is 0.006. The MAP also underwent a significant change with a P value of 0.0005. This result was similar to the study by Pinheiro et al. who found significant difference in the systolic and diastolic BP before and after giving respiratory physiotherapy. A significant reduction of the MAP was also noted.[14]

Klein et al. show that the RPP is frequently elevated by chest physiotherapy to a level which can lead to ischemia in cardiac patients.[15] Jellema et al. show that even though MHI causes increments in respiratory parameters, it did not cause significant change in the hemodynamic parameters which returned to baseline in 15 min.[16] Patman et al. further showed that even though MHI produced changes in HR, it was not of a magnitude that was considered to be clinically significant.[17]

It is observed, that there is a slight decrease in the RPP, but not in a statistically significant way with the P value of 0.409. The HR was found to be significantly higher after MHI and the P value was 0.048. As opposed to HR, there was a decrease in RR, even though the change was statistically significant. This study reinforces the same.

With this experimental study, we conclude that manual lung hyperinflation when applied as a standalone technique is also effective in bringing significant improvement to the RR, BP and other hemodynamic parameters. We can also conclude that even though the oxygenation increased, it was not statistically significant. This study shows that MHI affects the hemodynamic and oxygen parameters similar to all the other chest physiotherapy technique.

Acknowledgments

We would like to acknowledge Dr. Kalpesh Mallik, Dr. Ranjan Sengupta, Dr. Sanjay Pandey and all the Nursing Staff of the Care Hospital and Fortis Hospital, Raipur, India, for referring their patients for the study. All of them have generously donated many hours of their valuable time. We take this opportunity to express our heartfelt gratitude to the patients who consented to participate in the study.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Overend TJ, Anderson CM, Lucy SD, Bhatia C, Jonsson B, Timmermans C. The effect of incentive spirometry on post-operative pulmonary complications. Chest Sep 2001;120:971-8.  Back to cited text no. 1
    
2.
Lawrence VA, Hilsenbeck SG, Mulrow CD, Dhanda R, Sapp J, Page CP. Incidence and hospital stay for cardiac and pulmonary complications after abdominal surgery. J Gen Intern Med 1995;10:671-8.  Back to cited text no. 2
    
3.
Wilhelm M, Dirk V. The risk of postoperative pulmonary or pleural complications after aortic valve replacement is low in elderly patients: An observational study. Aust J Physiother 2008;54:119-24.  Back to cited text no. 3
    
4.
Blattner C, Guaranga JC, Saadi E. Oxygenation and static lung compliance is improved immediately after early lung manual hyperinflation following myocardial revascularization: A randomized control trial. Aust J Physiother 2008;54:173-8.  Back to cited text no. 4
    
5.
Klabunde RE. Cardiovascular Physiology Concepts: Mean Arterial Pressure. 2nd Edition, Lippincott Williams and Wilkins, 2012.  Back to cited text no. 5
    
6.
Maa SH, Hung TJ, Hsu KH, Hsieh YI, Wang KY, Wang CH, et al. Manual hyperinflation improves alveolar recruitment in difficult-to-wean patients. Chest 2005;128:2714-21.  Back to cited text no. 6
    
7.
Berney S, Denehy L. A comparison of effects of manual and ventilator hyperinflation on static lung compliance and sputum production in intubated and ventilated intensive care patients. Physiother Res Int 2002;7:100-8.  Back to cited text no. 7
    
8.
King D, Morell A. A survery on manual hyperinflation as a physiotherapy technique in ICU. Physiotherapy 1992;78:788-95.  Back to cited text no. 8
    
9.
Hodgson C, Ntoumenopoulos G, Dawson H, Paratz J. The Mapleson C circuit clears more secretions than the Laerdal circuit during manual hyperinflation in mechanically-ventilated patients: A randomised cross-over trial. Aust J Physiother 2007;53:33-8.  Back to cited text no. 9
    
10.
Sutherasan Y, Vargas M, Pelosi P. Protective mechanical ventilation in the non-injured lung: Review and meta-analysis. Crit Care 2014;18:211.  Back to cited text no. 10
    
11.
McCarren B, Chow CM. Manual hyperinflation: A description of the technique. Aust J Physiother 1996;42:203-8.  Back to cited text no. 11
    
12.
Cruz Santos RV, Andrade do Socorro da Silva Dias de F Menezes, Gonzaga de PD, et al. Manual hyperinflation and the role of physical therapy in intensive care and emergency units. Physiotherapy in Movement (Fisioterapia Em Movimento) 2017;30 Suppl 1:241-8.  Back to cited text no. 12
    
13.
Jones A, Hutchinson RC, Lin ES, Oh TE. Peak expiratory flow rates produced with the Laerdal and Mapleson-C bagging circuits. Aust J Physiother 38:210-5.  Back to cited text no. 13
    
14.
Pinheiro CH, Medeiros RA, Pinheiro DG, Marinho Mde J. Spontaneous respiratory modulation improves cardiovascular control in essential hypertension. Arq Bras Cardiol 2007;88:651-9.  Back to cited text no. 14
    
15.
Klein P, Kemper M, Weissman C, Rosenbaum SH, Askanazi J, Hyman AI. Attenuation of the hemodynamic responses to chest physical therapy. Chest 1988;93:38-42.  Back to cited text no. 15
    
16.
Jellema WT, Groeneveld AB, van Goudoever J, Wesseling KH, Westerhof N, Lubbers MJ, et al. Hemodynamic effects of intermittent manual lung hyperinflation in patients with septic shock. Heart Lung 2000;29:356-66.  Back to cited text no. 16
    
17.
Patman S, Jenkins S, Bostock S, Edlin S. Cardiovascular responses to manual lung hyperinflation in post-operative coronary artery surgery patients. Physiother Theory Pract 1998;14:5-12.  Back to cited text no. 17
    



 
 
    Tables

  [Table 1], [Table 2]



 

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